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This Article Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Google Scholar Articles by Groves, A. Articles by Ell, P. PubMed Articles by Groves, A. Articles by Ell, P.

Imaging hypertrophic obstructive cardiomyopathy (HOCM) on combined 82Rb PET/64 detector CT angiography: Initial experience

¹ Institute of Nuclear Medicine; ² Cardiology, UCL, London, United Kingdom; ³ Cardiology, NUH, Nottingham, United Kingdom

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Objectives: The initial experience of imaging HOCM atients with combined 82Rb-PET/64 detector-CT Angiography is described.

Methods: Ethics board clearance was obtained and patients gave informed consent. 15 consecutive patients (9 male, 6 female, mean-age 56.4years range 32-70years) with diagnosed HOCM, underwent integrated 82Rb-PET/CT angiography for suspected coronary artery disease. CT Images were reported by experienced readers for the presence of coronary artery stenoses and anomalies, and for left ventricular wall dimensions. The PET data was reported by experienced nuclear cardiology readers for perfusion defects and ejection fraction (EF).

Results: 6/15 had myocardial bridging (3 left descending artery, 2 right coronary artery (RCA) and 1 obtuse marginal). 2 patients had anomalous circulation (circumflex artery from the RCA and posterior descending artery from a marginal). One patient had a significant coronary stenosis on CT. The mean mid-septal thickness was 17.7mm (range 8.5-26.1mm. The mean septal:posterior wall-thickness ratio was 1.87. 5/15 patients had mild PET ischaemia. 4/15 had Rb septal hyperaemia. EF data was available in 12/15 patients. Mean EF was 52.7% at stress and 59.8% at rest. The EF was less at stress than rest in 10/12. The mean end-diastolic-volume was 120.0ml at stress and 103.6ml at rest. The mean end-systolic-volume was 57.4ml at stress and 42.6ml at rest.

Conclusions: The feasibility of performing combining 82Rb-PET/64 detector-CT Angiography in HOCM patients with suspected coronary artery disease is shown. This hybrid imaging reveals potential for yielding useful combined physiological and anatomical measurements in HOCM patients.

This Article Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Google Scholar Articles by Groves, A. Articles by Ell, P. PubMed Articles by Groves, A. Articles by Ell, P.