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This Article Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Google Scholar Articles by Morita, K. Articles by Hirokawa, Y. PubMed Articles by Morita, K. Articles by Hirokawa, Y.

Impaired myocardial blood flow reserve in patients with metabolic syndrome using PET-CT and N-13 labeled ammonia

¹ PET Center, Hiroshima Heiwa Clinic, Hiroshima, Japan; ² Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan

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Objectives: Cardiovascular risk factors cause abnormal coronary vasomotor response, and induce decreased myocardial blood flow reserve (MFR). In patients with metabolic syndrome, coronary vasomotor response may be impaired. However, the precise coronary vasomotor response abnormality in patients with metabolic syndrome defined Japanese criteria of metabolic syndrome (abdominal obesity with waist circumference over 85cm, and with two or three criteria; dyslipidemia, high blood pressure, and glucose intolerance) has not been elucidated. Therefore, the aim of this study is to assess myocardial blood flow (MBF) dynamics in patients with metabolic syndrome using N-13 labeled ammonia and PET-CT.

Methods: Fifteen male patients with metabolic syndrome (mean age: 56±3 years) with no definite evidence of heart disease, and age-matched controls (n=8) were enrolled in this study. MBF was measured at rest and during adenosine infusion,and MFR was calculated. In addition, visceral fat volume was measured using X-CT to compare to MBF parameters.

Results: MBF during adenosine infusion and MFR in patients with metabolic syndrome were lower than controls (1.85±0.26 vs 2.66±0.22 ml/g/min, p<0.05, 2.00±0.33 vs 3.36±0.78, p<0.01, respectively). In contrast, MBF at rest in metabolic syndrome tended to be higher than that of controls (0.93±0.08 vs 0.82±0.08 ml/g/min, NS). MFR was weakly correlated with visceral fat volume (p<0.05).

Conclusions: The results indicate that MBF measurement using PET-CT and N-13 labeled ammonia may be useful to evaluate coronary vasomotor abnormality, life modification effects and therapeutic intervention in metabolic syndrome.

This Article Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Google Scholar Articles by Morita, K. Articles by Hirokawa, Y. PubMed Articles by Morita, K. Articles by Hirokawa, Y.