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Cardiovascular: Clinical ScienceClinical Science Posters |
1 Molecular Imaging and Medicine Nuclear, Heart Institute (InCor) University School, São Paulo, Brazil, Sao Paulo, Sao Paulo, Brazil; ; 2 Radiology, Emory University, Atlanta, Georgia
844
Objectives: Left ventricular (LV) dyssynchrony assessed by phase analysis of gated myocardial perfusion scintigraphy (GMPS) correlates well with dyssynchrony assessed by tissue Doppler imaging. The aim of this study was to evaluate the effects of cardiac resynchronization therapy (CRT) on LV dyssynchrony assessed by GMPS and QRS duration according to LV performance changes on echocardiographic parameters.
Methods: Thirty five patients (pts) with end-stage heart failure and wide QRS complex were prospectively included in this study. Pre and post CRT, we analyzed QRS width, left ventricular end-diastolic diameter (LVEDD), LVEF by bi-dimensional echocardiography (Simpson’s rule), phase standard deviation (SD) and phase histogram bandwidth from phase analysis of GMPS. Post CRT, pts were divided into two groups according to LVEF improvement: group 1 (G1, 11 pts) with increase in LVEF 
5 points and group 2 (G2, 24 pts) without significant increase in LVEF.
Results: Post CRT, both groups decreased QRS width (p
0.01) but only G1 showed reduction in LVEDD (G1: from 75±14 mm to 68±18 mm, p=0.032; G2: from 77±10 mm to 78±12mm, p=0.695), phase histogram bandwidth (G1: from 154±72° to 100±60°, p=0.025; G2: from 187±89° to 181±90°, p=0.760) and phase SD (G1: from 50±20° to 33±17°, p=0.026; G2: from 59±26° to 55±23°, p=0.370).
Conclusions: CRT promoted improvement in cardiac performance in pts who showed reduction in LV dyssynchrony assessed by phase analysis of GMPS. However, QRS decrease was not associated to changes on LV function post CRT.
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