HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Google Scholar Articles by Ficaro, E. Articles by Corbett, J. PubMed Articles by Ficaro, E. Articles by Corbett, J.

Diagnostic accuracy of CT attenuation corrected myocardial SPECT imaging using quantitative methods

¹ Radiology, University of Michigan, Ann Arbor, Michigan; ² INVIA, Ann Arbor, Michigan

838

Objectives: Hybrid SPECT-CT imaging systems provide the ability to correct myocardial SPECT images for photon attenuation, scatter and collimator response to improve the detection of coronary artery disease (CAD). The objective of this study was to determine the diagnostic accuracy for CAD using standard quantitative methods.

Methods: A random selection of patients (n=156, 94 with angiographically confirmed disease, 62 low-likelihood nornals) referred for stress-rest Tc99m labeled myocardial perfusion SPECT imaging were imaged with a SPECT-CT system (Symbia T6, Siemens Medical Solutions, Hoffman Estates, IL). Breathhold CT acquisitions were acquired at end tidal expiration, 5-7sec acquisition time. SPECT images were acquired based on ASNC imaging guidelines. Images without corrections (NC) were reconstructed with standard methods while corrected (AC) images were reconstructed and corrected for photon attenuation (using CT data), scatter, and resolution recovery using manufacturers’ software. NC and AC images were quantified for defect size using Corridor4DM software (INVIA, Ann Arbor, MI) and compared to angiography results to determine the accuracy of the quantitative methods for the detection of CAD.

Results: For the detection of CAD at a 50% stenosis threshold, AC improved accuracy from 75% to 82% (p<0.02). Improvements were evident in both sensitivity (83% vs 73%, p=0.03) and specificity (82% vs 77%, p=NS). Using a 70% stenosis threshold, the advantages were still evident but with lower statistical certainty.

Conclusions: Hybrid SPECT-CT myocardial perfusion imaging provided improved accuracy for the detection of CAD using quantitative methods. For this patient population, most of the benefit of AC imaging was seen in the improved detection of intermediate grade stensoses.

This Article Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Google Scholar Articles by Ficaro, E. Articles by Corbett, J. PubMed Articles by Ficaro, E. Articles by Corbett, J.