J Nucl Med. 2008; 49 (Supplement 1):188P
Cardiovascular: Clinical ScienceClinical Science Posters |
Normal profiles of longitudinal base-mid-apex coronary flow reserve gradient in healthy volunteers as measured by Rb-82 PET
Jongho Kim1,
Rafique Ash1,
Arlene Travis1 and
Josef Machac1
1 Division of Nuclear Medicine, Department of Radiology, Mount Sinai School of Medicine, New York, New York
821
Objectives: Longitudinal Base-to-Apex coronary flow reserve (CFR) gradients has been observed during hyperemia in patients with CAD or risk factors (Gould et al, Schelbert et al). The aim of this study was to define Base-to-Mid and Mid-to-Apex rest-, stress-flow and CFR Gradient in normal volunteers.
Methods: We studied 21 normal volunteers (39±12 yrs; F/M=9/12) who underwent rest and pharmacologic stress Rb-82 PET myocardial perfusion imaging. Global and regional rest- and stress-flow and CFR in each of the coronary territories were measured using the method of Yoshida et al (JNM 1996). % Base-to-Mid gradient was calculated as {[(Base-Mid) /(Base+Mid)] x 200} and % Mid-to-Apex gradient as {[(Mid-Apex) / (Mid+Apex)] x 200}.
Results: In 21 normal volunteers, mean global Base-Mid-Apex CFR was 2.74-2.73-2.66, respectively. At rest and stress, there was no significant Base-to-Mid flow gradient, while there was uniform significant Mid-to-Apex flow gradient. There was no or minimal CFR gradient.
Conclusions: In normal volunteers, there was no or minimal CFR gradient in all three coronary artery territories, although both rest- and stress-flow showed significant Mid-to-Apex gradient. The cause of this progressive Mid-to-Apex flow gradient is unclear.
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BM and MA flow and CFR Gradients (%)
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