J Nucl Med. 2008; 49 (Supplement 1):188P
Cardiovascular: Clinical ScienceClinical Science Posters |
Left ventricular (LV) dyssynchrony measured by phase analysis of gated FDG PET studies predicts cardiac death in patients with ischemic cardiomyopathy
Cesar Santana1,
Liudmila Verdes1,
Ji Chen1,
Fabio Esteves1,
C. David Cooke1,
Tracy Faber1,
Russel Folks1 and
Ernest Garcia1
1 Radiology, Emory University, Atlanta, Georgia
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Objectives: Determine the diagnostic performance of phase analysis in the stratification of patients with ischemic cardiomyopathy.
Methods: 104 consecutive patients (mean age:63±10, female:18%) with CAD and previous MI who had undergone rest Rb-82/ECG-Gated FDG PET, to assess myocardial viability were studied. LV dyssynchrony was measured by the phase distribution obtained using Fourier analysis of regional LV thickening from rest Gated FDG PET studies. The primary endpoint was cardiac death.
Results: During the follow-up period (5.07±2.44 years), 55 patients died. The univariate analysis shows no statistically significant differences between patients who died and patients who were alive by peak phase: death 125,alive 135,p=0.5, phase SD: death 72.9,alive 74.7,p=0.65, skewness: death 2.1,alive 2.0,p=0.69 and kurtosis: death 5.9, alive 5.6,p=0.79. Bandwidth was the only significant predictor of death in the univariate analysis: death 200, alive 171,p=0.02. A censored survival analysis using a Kaplan-Meier method and pre-determined thresholds by ROC analysis showed a statistically significant difference between patients who died and those who were alive for phase SD and bandwidth.
Conclusions: Bandwidth and phase standard deviation calculated from the Gated FDG PET are useful for the long term stratification of patients with ischemic cardiomyopathy undergoing myocardial viability assessment.
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Survival analysis using a Kaplan-Meier method.
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