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J Nucl Med. 2008; 49 (Supplement 1):187P
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Cardiovascular: Basic Science

Basic Science Posters

Cardiac imaging and uptake of BMS747158-02 under various experimental conditions

Ming Yu1, Mary Guaraldi1, Mikhail Kagan1, Michael Azure1 and Simon Robinson1

1 BMS Medical Imaging, N. Billerica, Massachusetts

814

Objectives: BMS747158-02 is an 18F labeled mitochondrial complex I (MC-I) inhibitor being developed for PET myocardial perfusion imaging. This study examined the impact of feeding state and anesthetic on cardiac imaging and uptake of this agent in rats in comparison to 18F-fluorodeoxyglucose (FDG).

Methods: Feeding state was examined in rats nonfasted or fasted for 20 hours. Anesthetic effects were examined in sodium pentobarbital (SP) or ketamine and xylazine (KX) anesthetized rats. Tissue biodistribution at 60 min post injection and cardiac PET imaging studies were performed with 18F labeled MC-I inhibitor (BMS747158-02 or 18F-RP1003) or FDG. Blood glucose levels were also measured before anesthesia and at euthanasia.

Results: The blood glucose levels were 91±2 and 123±3 mg/dL in fasted and nonfasted rats before anesthesia, and changed by 4±5 and 13±9 mg/dL respectively when anesthetized with SP. However, the levels increased markedly by 65±8 and 257±89 mg/dL in fasted and nonfasted rats anesthetized with KX. The heart uptake of FDG was significantly lower in fasted than nonfasted rats (0.2±0.0 vs. 3.1±0.5% injected dose per gram tissue: %ID/g). However, the heart uptake of BMS747158-02 did not differ under these conditions (2.8±0.1 vs. 2.8±0.8 %ID/g). In nonfasted rats, the heart uptake of FDG was markedly lower when anesthetized with KX than with SP (0.2±0.0 vs. 3.1±0.5%ID/g). In contrast, the heart uptake of 18F-RP1003 was similar with both anesthetics (3.0±0.2 vs. 3.0±0.2%ID/g). Consistently, the myocardium was not visible following FDG imaging in fasted rats, but clearly seen in both fasted and nonfasted rats with BMS747158-02.

Conclusions: Unlike FDG, BMS747158-02 cardiac images are clear and not affected by the feeding state and anesthetic.





This Article
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Google Scholar
Right arrow Articles by Yu, M.
Right arrow Articles by Robinson, S.
PubMed
Right arrow Articles by Yu, M.
Right arrow Articles by Robinson, S.