| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
|
|
|||||||||
|
|
Cardiovascular: Basic ScienceBasic Science Posters |
1 Radiology, Duke University Medical Center, Durham, North Carolina; 2 Radiology, University of Pennsylvania, Philadelphia, Pennsylvania; 3 Radiology, Long Island Jewish Medical Center, New York, New York
813
Objectives: To determine the correlation of left ventricular (LV) volume measurements in mice from 99mTc RBC ECG gated blood pool (GBP) SPECT using a rapid, automated analysis program (BP-SPECT) and values obtained from MRI.
Methods: Normal control C57/B6 mice (n=10) underwent paired GBP SPECT and gated MRI imaging studies. Both were performed under similar temperature and heart rate control to match physiologic parameters. SPECT was acquired with 1.0 mm pinhole collimation on a 3-detector system; MRI images were acquired using a 3D radial cine acquisition with a liposomal gadolinium blood pool agent. Both studies were acquired using high spatial and temporal resolution (16 frames/ECG cycle). Blinded visual and quantitative analysis of LV end-diastolic, end-systolic volumes, and LVEF was performed. Left ventricular synchrony was also automatically computed by BP-SPECT. SPECT LV volumes were assessed for correlation with MRI by linear regression; differences in LVEF between SPECT and MRI were assessed by paired student’s t-test.
Results: Visual analysis of GBP SPECT and MRI demonstrated normal LV wall motion in all mice. LV volumes by SPECT showed good linear correlation with end diastolic and end-systolic volumes from MRI (SPECT volume=1.1 MRI volume-4.16; r=0.90; n=20). LVEF was >50% by BP-SPECT and MRI for all mice. LVEF for SPECT was not significantly different compared to MRI (62.1%+7.7% vs 57.4%+3.3%; p=0.10).
Conclusions: BP-SPECT LV volumes show good correlation with MRI LV volumes. BP SPECT can also rapidly quantify LV regional synchrony in normal mice.
| ||||||||||||||||||||||||||||||||||||||
