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This Article Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Google Scholar Articles by Groves, A. Articles by Ell, P. PubMed Articles by Groves, A. Articles by Ell, P.

Imaging 18F-FDG vascular uptake: Recent data from a latest PET/CT machine

¹ Institute of Nuclear Medicine, UCL, London, United Kingdom; ² Vascular Surgery, Brighton and Sussex County Hospital, Brighton, United Kingdom

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Objectives: It is recommended that arterial wall 18FDG uptake is imaged at 3 hours. This was based on data from a PET only system where physical coregistration with CT was not possible and from 8 patients. We used the latest generation of PET/CT machine to investigate the ideal imaging times to measure vascular uptake post injection of 18F-FDG.

Methods: Over a month we performed 18F-FDG PET/CT examinations on 11 male patients (mean age 74.8y range 61-82y) under scientific investigation for atheroma in the abdominal aorta using a PET/64-detector-CT (GE VCT-XT Discovery). Following injection of 18F-FDG we performed dynamic imaging using 2 minute frames between 45-53, 57-65, 115-123 and 175-183 minutes. Coregistration and image analysis was performed using a Xeleris workstation. Regions of interest (ROI) were drawn over the abdominal aortic wall. The maximum activity concentration for each region was recorded in each 2 minute frame. For each period of dynamic imaging, the mean maximum activity concentration (corrected for decay)and its associated standard error was derived. This was repeated in each of the 11 patients and mean values derived.

Results: The mean aortic wall maximal activity concentration was 3791.57, 4117.85, 3689.61 and 4903.42 at 45-53, 57-65, 115-123 and 175-183 minutes respectively. The mean standard error was 203.89, 197.77, 191.61 and 337.88 respectively.

Conclusions: The arterial wall 18FDG (corrected)uptake was slightly higher at three hours than at one hour post injection. However, the arterial wall uptake is more variable at 3 hours than at an hour. There was no significant advantage in imaging at three hours over one hour.

Research Support: The Royal College of Radiologists part-funded this work.

This Article Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Google Scholar Articles by Groves, A. Articles by Ell, P. PubMed Articles by Groves, A. Articles by Ell, P.