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J Nucl Med. 2008; 49 (Supplement 1):182P
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Cardiovascular: Basic Science

Basic Science Posters

Myocardial perfusion imaging with 99mTc-N-DBODC5 in canine model of acute myocardial ischemia

Zhang Wanchun1, He Zuoxiang2, Fang Wei2, Li Bin3 and Wang Xuebin3

1 Nuclear Medicine, 1st Hospital of Shanxi Medical University, Taiyuan, Shanxi, China; 2 Nuclear Medicine, Fu Wai Hospital, Peking Union Medical College, Beijing, China; 3 College of Chemistry, Beijing Normal University, Beijing, China

797

Objectives: 99mTc-N-DBODC5 is a new myocardial perfusion tracer shown to exhibit high heart uptake and rapid liver clearance. The objectives of this study were to assess the characteristics of 99mTc-N-DBODC5 myocardial imaging in canine models of acute myocardial ischemia, and compared with 99mTc-MIBI.

Methods: Twelve adult beagle dogs were included in this study. The left anterior descending artery (LAD) was occluded to make a critical stenosis (>90%), then, adenosine was infused intravenously at a rate of 0.14mg/kg.min for 6min. At the end of 3min of adenosine infusion, 185MBq of 99mTc-N-DBODC5 or 99mTc-MIBI (randomly) was injected intravenously. The occluder was released after adenosine infusion. Serial myocardial SPECT imaging acquisitions were obtained 0.5, 1, 1.5 and 2h respectively after injection. Rest myocardial SPECT imaging was acquired in the next day.

Results: 99mTc-N-DBODC5 exhibited high heart uptake and minimal lung uptake, that was similar with 99mTc-MIBI. No significant myocardial washout was observed with both tracers over 2 hours. 99mTc-N-DBODC5 clearance from the liver was obviously more rapid than that with 99mTc-MIBI (heart-liver radio at 60min, 1.36±0.43 versus 0.58±0.21, P=0.005). Number of Myocardial segments with perfusion defects by 99mTc-N-DBODC5 was 3.60±1.52, and 4.25±0.96 by 99mTc-MIBI (P=0.48). Like 99mTc-MIBI, 99mTc-N-DBODC5 showed minimal redistribution.

Conclusions: With the exception of the more rapid liver clearance, many properties of 99mTc-N-DBODC5 that were observed in this study were comparable to those of 99mTc-MIBI. So improved organ biodistribution properties make 99mTc-N-DBODC5 a promising new myocardial perfusion agent.





This Article
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