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J Nucl Med. 2008; 49 (Supplement 1):163P
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Novel Approaches to Molecular Imaging

Novel Approaches to Molecular Imaging Posters

A multimodality wrist restraint system for high resolution PET/CT and MR imaging in rheumatoid arthritis

Abhijit Chaudhari1, G. Burkett2, R. Harse3, S. Bowen1, N. Packard1, S. Naguwa4, J. Hunter2, M. Buonocore2, R. Stern3 and R. Badawi2

1 Biomedical Engineering, UC Davis, Davis, California; 2 Radiology, UC Davis Medical Center, Sacramento, California; 3 Radiation Oncology; 4 Internal Medicine, UC Davis, Davis, California


Formula

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Objectives: 3D anatomical (CT and MRI) and functional (PET and DCE-MRI) imaging of the wrist would be highly desirable for probing response to therapy in Rheumatoid Arthritis (RA), since changes in imaging metrics, e.g. synovial thickness, FDG-SUV, contrast, erosion, etc, can be monitored over time and in turn may be linked to the clinical status of the disease [1,2]. The aim of this study was to design and fabricate an ergonomic wrist restraint system (WRS) compatible with a MRI scanner and the UC Davis dedicated high resolution extremity PET/CT scanner. This setup is expected to yield better anatomical correlation between images from the two scanners.

Methods: The WRS consisted of a styrofoam base on which the forearm could be rested in either the prone or supine position. A thermoplastic sheet was used to create a mask for the wrist. The mask was appropriately locked in position on the base by means of nylon bolts. A plastic frame for MRI and a center stage for PET/CT supported the WRS to lie along the central axes of the scanners.

Results: The multimodality WRS was designed and fabricated. Studies determining the accuracy of repositioning are being conducted. A proposal for conducting patient scans is funded and has been submitted to the IRB.

Conclusions: Coregistered high resolution anatomical and functional data to be acquired using the proposed setup should facilitate the investigation of indicators of positive or negative response to therapy in RA.

Research Support: NIH-NCRR UL1 RR024146 UC Davis Clinical and Translational Sciences Center Pilot Award, the UC Davis Imaging Research Center and the Rusch Fund for Nuclear Medicine.





This Article
Services
Right arrow Email this article to a friend
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Right arrow Alert me to new issues of the journal
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Google Scholar
Right arrow Articles by Chaudhari, A.
Right arrow Articles by Badawi, R.
PubMed
Right arrow Articles by Chaudhari, A.
Right arrow Articles by Badawi, R.