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J Nucl Med. 2008; 49 (Supplement 1):162P
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Novel Approaches to Molecular Imaging

Novel Approaches to Molecular Imaging Posters

FDG PET/CT aids the management of IBD patients suspected of disease flare-up

Demetrios Agriantonis1, Scott Perlman1, Bret Spier2, Christine Jaskowiak1 and Mark Reichelderfer2

1 Radiology, Div NM, University of Wisconsin Hospital and Clinics, Madison, Wisconsin; ; 2 Medicine, Div Gastroenterology/Hepatology, U Wisconsin, Madison, Wisconsin

705

Objectives: To determine if FDG PET/CT findings can help guide management decisions in patients with suspected active inflammatory bowel disease (IBD).

Methods: Eleven patients with inflammatory bowel disease- 6 Crohn’s disease (CD), 5 ulcerative colitis (UC)- were studied with F-18 FDG PET/CT between April 2005 and September 2007 during the management of suspected disease flare-ups. The scans were scored by an experienced PET physician who was blinded to the clinical information. An abnormal scan was defined as having at least one bowel segment with activity greater than that of the liver. Five bowel regions were assessed: small bowel, ascending, transverse, descending, and rectosigmoid colon. The PET results were compared to clinical disease activity/endoscopy/pathology results and treatment regimen at the time of the study to determine if there was a correlation between scan appearance and clinical course.

Results: Six patients (3 CD, 3 UC) had active inflammation requiring an altered treatment regimen. All of these patients had a positive PET scan. Colonoscopy with biopsy was performed in all 6 patients with active inflammation, and there was excellent agreement between these and the PET scan findings. Five patients had stable disease that did not require a treatment change. Of these patients, 4 had a normal scan, and there was one false positive scan.

Conclusions: These preliminary data suggest that FDG PET/CT may be helpful in the management of IBD patients suspected of disease flare-up. A positive PET scan is likely to correspond with an abnormal endoscopy, and these patients are expected to require a change in treatment regimen.

Research Support: Procter and Gamble Pharmaceuticals





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Right arrow Email this article to a friend
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Right arrow Articles by Agriantonis, D.
Right arrow Articles by Reichelderfer, M.
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Right arrow Articles by Agriantonis, D.
Right arrow Articles by Reichelderfer, M.