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This Article Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Google Scholar Articles by Winant, C. Articles by Hasegawa, B. PubMed Articles by Winant, C. Articles by Hasegawa, B.

Use of 94Tc-MIBI PET data to model dynamic cardiac SPECT

¹ Radiology, UCSF, San Francisco, California; ² CC, MCI, NIH, Bethesda, Maryland

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Objectives: The use of fast dynamic SPECT to quantify MBF is limited by its acquisition geometry which can produce inconsistent projections and reconstruction artifacts with rapidly changing distributions of radioisotope. Processing and injection schemes have been proposed to minimize these effects, but are difficult to assess in humans, are difficult to model accurately by computer simulation, and are time-consuming and expensive to evaluate with animal experiments. We therefore developed methods that use 94Tc-MIBI dynamic cardiac data acquired with PET in human volunteers to model dynamic SPECT MIBI projection data. Comparing the reconstructed SPECT with the time averaged PET data from actual patient data realistically models dynamic SPECT perfusion data using the true biological MIBI distribution in space and time.

Methods: Six 2-hr dynamic 94Tc-MIBI human PET studies (GE Advance) were performed. The PET data were used to model a series of 240-sec SPECT acquisitions by forward-projecting the PET data at 60 equally-spaced angles (each from a different time point) over a range of 180 degs. The SPECT data were reconstructed and compared to the equivalent time averaged PET data.

Results: A variety of SPECT acquisition parameters can be evaluated (time range, angular sampling, number of heads, etc).Visual comparisons of 94Tc-MIBI "SPECT from PET" data vs. actual time averaged PET data were made to assess degree of artifact, and quantification.

Conclusions: As expected, early first transit data is problematic with dynamic SPECT unless multiple angles are sampled simultaneously (e.g., using multiple heads). One can also assess processing methods proposed to reduce SPECT artifacts. The method could be extended to iodinated compounds, using 124I PET.

This Article Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Google Scholar Articles by Winant, C. Articles by Hasegawa, B. PubMed Articles by Winant, C. Articles by Hasegawa, B.