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Oncology-Clinical Diagnosis: Solid TumorsSarcoma |
1 Nuclear Medicine, Yeungnam University Hospital, Daegu, South Korea; 2 Pathology; 3 Orthopedics, Yeungnam University Hospital, Taegu, South Korea
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Objectives: F-18 FDG PET and MRI are useful in differentiating malignant tumors from benign lesions in musculoskeletal tumors, while certain tumors have no F-18 FDG uptake or distinguishing signal characteristics. This retrospective analysis compared the accuracies of F-18 FDG PET/CT and MRI in the differentiation of malignant and benign musculoskeletal tumors.
Methods: Seventy patients with primary musculoskeletal tumors (37 male, mean age: 41 ± 20 years old) were studied and all patients underwent F-18 FDG PET/CT and MRI before treatment. Final diagnosis was confirmed by histologic tissue biopsy. The patients were divided two groups with soft tissue tumor (n=36) and bone tumor (n=34).
Results: Sensitivity, specificity, and negative and positive predictive values of F-18 PET/CT and MRI for the differentiation of malignant and benign soft tissue tumors were 75/60%, 75/87.5%, 78.9/85.7% and 70.6/63.6%m, respectively. Sensitivity, specificity, and negative and positive predictive values of F-18 PET/CT and MRI for the differentiation of malignant and benign bone tumors were100/52.6%, 40/93.3%, 67.9/90.9% and 100/60.9%, respectively. There was significant difference in max SUV of benign ( 3.2 +/- 3.0) and malignant ( 10.1 +/- 7.5 ) bone tumor in older than 20 years (P<0.01) and specificity of F-18 FDG PET/CT was increased from 40% to 80%.
Conclusions: Diagnostic accuracy was not significantly different in soft tissue tumor between PET/CT and MRI in soft tissue tumor, but PET/CT have high NPV and MRI high PPV in bone tumor. Especially, the specificity of bone tumor was significantly increased in the patients over age 20.
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