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J Nucl Med. 2008; 49 (Supplement 1):13P
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Radiopharmaceutical Chemistry: Special Sessions

Radiopharmaceutical Sciences Council Young Investigator Award Symposium

Automated and repetitive production of PET tracers with µ-fluidics: A "faster lab"

Gjermund Henriksen1, Bent Schoultz1, Karl Jansen2 and Hans Wester1

1 Nuclear Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany; 2 ScintOmics, Fuerstenfeldbruck, Germany

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Objectives: Development of fast tracer production systems to meet the demands of imaging labs. These systems should improve the feasibility of tracer production and increase the multi-dose/multi-tracer availability for repetitive animal/human PET-studies in a cost efficient manner.

Methods: A simple instrumental set-up was chosen: 1) µ-fluidic components made of different inert polymers, 2) solvent delivery by µ-pumps, 3) small solvent mixing chambers, 4) radioactivity sensors controlling fractionation and further processing, 5) removal of protective groups, 6) solid phase extraction by controlled dilution and fixation for removal of impurities and 7) on-line formulation, preceded by in-line HPLC, if required.

Results: At concentrations of 1µmol FDG- or FLT-precursors/100µl, 18F-fluorinations in MeCN resulted in >85% incorporation of 18F at a flow rate of 0.3ml/min (0.15-0.6 ml/min) within 40s. Both tracers were deprotected in either 0.15M NaOH or 1M HCl within 40s-5min at 40°C-90°C, depending on the geometry of the "chamber or tubing". The entire method allowed for the production of crude FLT and injectable solutions of FDG within 7-8 min. Sequential syntheses were performed for either the repetitive provision of one tracer, or even the production of different tracers, with consistently high reproducibility and robustness.

Conclusions: Although µ-fluidic approaches to PET tracers have already been reported and commercialized, the simple and comparatively cheap instrumental set-up employed allowed production of tracers with remarkable efficiency, in high yields, in a repetitive manner, and under fully automated conditions.





This Article
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Right arrow Alert me to new issues of the journal
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Right arrow Articles by Wester, H.
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Right arrow Articles by Wester, H.