J Nucl Med. 2008; 49 (Supplement 1):137P
General Clinical Specialties: Renal/Electrolyte/HypertensionNephro-Urology |
Utility of 99m-Tc-MAG3 renal scintigraphy in assessing cisplatin-induced nephrotoxicity
T. Zehra1,
M. Sohaib2,
S. Saeed2,
A. Khan3,
R. Jafri1 and
J. Irfan1
1 Dept of Nuclear Medicine, Nuclear Medicine, Oncology and Radiotherapy Institute (NORI), Islamabad, Pakistan;
2 Dept of Medical Sciences, Pakistan Institute of Engineering and Applied Sciences (PIEAS), Islamabad, Pakistan;
3 Dept of Diagnostic Imaging, North Manchester General Hospital, Manchester, United Kingdom
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Objectives: To see the usefulness of dynamic renal scintigraphy using the tubular agent 99m-Tc-MAG3 in assessing nephrotoxicity of cisplatin, a cytotoxic chemotherapeutic agent.
Methods: Ten patients of solid tumors, destined to receive cisplatin-based chemotherapy, were included in the study. Dynamic renal scanning was done twice using 99m-Tc-MAG3; first, as a baseline study, and secondly, at an interval of about six weeks of first dose of therapy. The study was analyzed qualitatively and quantitatively, viz. count-based renogram generation, calculating time to maximum activity (T-max), time to half the maximum activity (T-1/2max), Total Renal Uptake (TRU) determination by camera-based method and calculation of Effective Renal Plasma Flow (ERPF) by Bubeck’s post-injection, single-plasma-sample method, in each study.
Results: T-max and T-1/2max values showed no significant rise following cisplatin administration (p-values 0.4 and 0.5 respectively). TRU revealed a fall (p-value 0.1), less significant, however, than did ERPF (p-value 0.001).
Conclusions: Single-sample based method (ERPF) using 99m-Tc-MAG3 can be used clinically to assess renal tubular toxicity following i.v. cytotoxic drugs. Gamma-camera methods are less significant in this respect.
