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J Nucl Med. 2008; 49 (Supplement 1):122P
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Instrumentation & Data Analysis: Data Analysis & Management

Oncology

Kinetic analysis of 18F-fluoride PET images of breast cancer bone metastases

Robert Doot1, Mark Muzi1, Lanell Peterson1, Erin Schubert1, Julie Gralow2, Jennifer Specht2 and David Mankoff1

1 Division of Nuclear Medicine, University of Washington, Seattle, Washington; 2 Division of Medical Oncology, University of Washington and Seattle Cancer Care Alliance, Seattle, Washington


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Objectives: The most common site of metastasis for breast cancer is bone. Bone metastases from breast cancer present with phenotypes ranging from primarily osteoblastic to largely lytic lesions. Skeletal kinetics of normal, osteoporotic, and Paget’s diseased bone have been studied using 18F-fluoride PET tracer. The purpose of this analysis was to evaluate the 18F-fluoride model for characterizing bone metastases in breast cancer patients and measuring response.

Methods: Eleven metastatic breast cancer patients underwent dynamic 18F-fluoride PET imaging that included venous blood and plasma activity measurements. Activity concentrations in the left ventricle, a representative bone metastasis and a normal vertebra were measured using ROI analysis. Using parametric values from this data set, model sensitivity and accuracy were studied.

Results: The average plasma to whole blood ratio of 18F-fluoride concentrations ratio was 1.2 ±0.2 (±standard deviation). Fluoride flux and initial transport for metastases (Ki = 0.10 ±0.04 mL/min/mL and K1 = 0.17 ±0.07 mL/min/mL) were both significantly higher than for normal bone (Ki = 0.05 ±0.03 mL/min/mL and K1 = 0.11 ±0.06 mL/min/mL, p < 0.01). The correlation between Ki and K1 was lower for metastases (R2 = 0.40) than for normal vertebrae (R2 = 0.63), suggesting a wider range of phenotypes in the metastases.

Conclusions: Fluoride flux and transport can be accurately and independently measured for bone metastases and normal vertebrae. Future studies will test the correlation of parameters to biologic features of bone metastases and to response to therapy.

Research Support: CA42045, CA72064, and CA124573





This Article
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
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Right arrow Articles by Doot, R.
Right arrow Articles by Mankoff, D.
PubMed
Right arrow Articles by Doot, R.
Right arrow Articles by Mankoff, D.