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Instrumentation & Data Analysis: InstrumentationPre-Clinical Imaging |
1 Kobe City College of Technology, Kobe, Japan; 2 Osaka University Graduate School of Medicine, Osaka, Japan; 3 Nara Institute of Science and Technology, Nara, Japan; 4 Institute for Biological Research and Innovation, Kobe, Japan
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Objectives: Continuous blood sampling for quantitative measurement of small animal PET studies is difficult because of the limited blood of small animals. Also the distance from the animal to detector must be small to minimize the amount of sampling blood. For this purpose, we developed and tested a high sensitivity and small size continuous blood sampling positron detector with background rejection capability.
Methods: The positron detector consists of a pair of dual-layer 0.5mm thick GSO scintillators with different decay time (35ns and 60ns) optically coupled to a square photo-multiplier tube (PMT). By using the pulse shape analysis, count rate of these two GSOs can be discriminated. Front layer detects positron and background gamma photons while back layer detects background gamma photons. By subtracting the count rate of latter from that of the former, the background rejected count rate of positron can be estimated.
Results: Energy spectrum showed single 511-keV peak and pulse shape spectrum showed clear separation of two types of GSOs. The size of the positron detector could be reduced to be 4cm x 4cm x 8cm. Sensitivity was 8.6% and 24% for F-18 and C-11 positrons, respectively. Artery time activity curve (TAC) could be successfully obtained for rat FDG study with high background gamma environment.
Conclusions: The developed positron detector is compact, high sensitivity and insensitive to background counts. With these results, the developed positron detector will be a powerful tool for small animal PET quantitative studies.
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