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Oncology-Clinical Diagnosis: Solid TumorsNeuroendocrine and Head & Neck Cancers |
1 Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India
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Objectives: 68GalliumDOTATOC (G-PET) is a recent addition in the armamentarium of functional imaging. We evaluated G-PET with F-PET and CI procedures in carcinoid tumors.
Methods: Twentyfive patients (M: 16, F: 9; mean 45.8 yrs ) of known carcinoid tumors were included in the study. 16 patients had already undergone some form of treatment (surgery 13; chemotherapy 3; octreotide therapy in 5), had histopathological confirmation of the diagnosis and were sent for restaging/monitoring response to therapy. Remaining 9 patients had lesions in liver/lymph nodes, which on FNA revealed carcinoid and now were being evaluated for primary. Results of CI were available with all and underwent G-PET and F-PET in our department.
Results: G-PET showed abnormal foci of increased tracer uptake in 14/16 patients, F-PET in 8/16 while CI showed lesions in 11/16 patients. In the remaining 9 patients primary tumors were detected in 6/9 by G-PET, none on F-PET-and 2/9 by CI. G- PET enabled best localization of primary tumors and lymph node staging. These findings changed management in 12/25 patients with 7 of them undergoing surgery and rest octreotide therapy.
Conclusions: 68Ga-DOTATOC PET (G-PET) is a superior imaging modality in the investigation of carcinoid tumors both for restaging as well as in localizing primary tumors.
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