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J Nucl Med. 2008; 49 (Supplement 1):112P
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Oncology-Clinical Diagnosis: Solid Tumors

GI Cancers - Colorectal and Liver

Assessment of the metabolic-perfusion relationship in primary colorectal adenocarcinoma using integrated 18- FDG PET/CT and perfusion CT

Ashley Groves2, Vicky Goh1, Manuel Rodriguez-Justo2, Alec Engeldow2, Irfan Kayani2, Stuart Taylor2, Steve Halligan2 and Peter Ell2

1 Mount Vernon Hospital, Northwood, United Kingdom; 2 University College Hospital, London, United Kingdom

445

Objectives: To assess the metabolic- perfusion relationship of primary colorectal adenocarcinoma at staging using 18- FDG PET-/CT and Perfusion CT.

Methods: Following institutional review board approval 10 prospective patients (7 male, 3 female, mean age 65.7years) with proven colorectal adenocarcinoma underwent imaging on a 64 detector PET/CT instrument (VCT Discovery, GE Healthcare). Immediately following the FDG PET study (190 MBq tracer IV; 60 minute uptake period; 2D acquisition; 10 minute per bed position), Perfusion CT study was performed (IV bolus 50 mls iohexol 350mg/ml; 4cm coverage; acquisition interval 2 sec; 150 sec study). Tumour SUVmax was recorded for each patient. Tumor blood flow, blood volume and permeability surface area product were determined using distributed parameter analysis (Perfusion 3.0 software, GE Healthcare). SUVmax and vascular parameters were compared using Pearson correlation; statistical significance was at 5%.

Results: 9/10 patients underwent surgery. Tumors were located in the cecum (3), sigmoid (4) and rectosigmoid (2); T stage: T3 (6), T4 (3); Dukes’ Stage: B (4), C/D (6). Mean (SE) SUVmax was 17.6 (1.2). Mean (SE) for tumor blood flow, volume and permeability surface area product were 90.7 (12.9) ml/min/100g tissue, 5.77 (0.51) ml/100g tissue, and 13.8 (2.5) ml/min/100g tissue. No correlation between vascular parameters and SUVmax was noted for higher stage tumors (Dukes’ C/D); there was a positive correlation between blood flow and volume and SUVmax for lower stage tumors (Dukes’ B) just above significance (r= 0.7, 0.9 respectively; p=0.07).

Conclusions: The metabolic- perfusion relationship is not consistent in colorectal cancer but may depend on stage.





This Article
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Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Google Scholar
Right arrow Articles by Groves, A.
Right arrow Articles by Ell, P.
PubMed
Right arrow Articles by Groves, A.
Right arrow Articles by Ell, P.