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J Nucl Med. 2008; 49 (Supplement 1):110P
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Oncology-Basic Science: Therapy, Metrics & Intervention

Translational Nuclear Medicine - Pre-Clinical Therapy

Image-guided interventional cancer therapy with 186Re-liposomes

Ande Bao1, Beth Goins1, Sean Wang2, Xavier Garcia-Rojas1, Anuradha Soundararajan1, Randal Otto2, Gerald Dodd1 and William Phillips1

1 Radiology; 2 Otolaryngology - Head and Neck Surgery, University of Texas Health Science Center at San Antonio, San Antonio, Texas

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Objectives: Image-guided administration of nanoparticle-carried β-emitting therapeutic radionuclides into tumor interstitial space may have broad application in treating various solid cancers by allowing for high local tumor retention of radioactivity and low normal tissue toxicity. We report 186Re-liposome distribution and therapy response after interstitial administration into head and neck squamous cell carcinoma (HNSCC) xenografts in nude rats.

Methods: Various liposome formulations were labeled using 186Re-BMEDA. 186Re-liposomes were administered intratumorally (tumor size: 1.25±0.14 cm3; 8 mCi/cm3 tumor) or intraoperatively (tumor remnant: 0.5-1.0 cm3, 4.8±0.4 mCi for neutral liposomes and 3.9±0.2 mCi for cationic liposomes). MicroSPECT/ CT imaging was performed to determine 186Re retention and micro-distribution. Changes in tumor volume, body weight and hematology were monitored.

Results: High local retention with a broad area of intratumoral diffusion after intratumoral and intraoperative administration of 186Re-liposomes was observed in images. Tumors were 2.05±0.76 cm3 (n=3) at day-20 after intratumoral 186Re-PEG liposome therapy while control tumors reached 7.58±2.67 cm3 by day-14 (n=4). Tumors were 0.75±0.75 and 0.58±0.67 cm3 by day-35 after intraoperative therapy with 186Re-neutral liposomes (n=8) or 186Re-cationic liposomes (n=8), while control tumors reached 8.02±3.49 and 8.30±1.83 cm3 by day-15 (n=4 each). No significant systemic toxicity was observed in treated animals.

Conclusions: Image-guided interstitial radionuclide therapy has promise for solid tumor therapy with reduced normal tissue toxicity.





This Article
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Right arrow Email this article to a friend
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Right arrow Alert me to new issues of the journal
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Right arrow Articles by Bao, A.
Right arrow Articles by Phillips, W.
PubMed
Right arrow Articles by Bao, A.
Right arrow Articles by Phillips, W.