SNM Annual Meeting Abstracts
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     



J Nucl Med. 2008; 49 (Supplement 1):107P
This Article
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Google Scholar
Right arrow Articles by de Langen, A. J
Right arrow Articles by Lammertsma, A. A
PubMed
Right arrow Articles by de Langen, A. J
Right arrow Articles by Lammertsma, A. A

Oncology-Basic Science: Therapy, Metrics & Intervention

Technical Issues, Reproducibility and Quantification

Reproducibility of quantitative measurements with [18F]FLT-PET

Adrianus J de Langen1, Bianca M Klabbers1, Mark Lubberink1, Ronald Boellaard1, Ben J Slotman1, Remco de Bree1, Egbert F Smit1, Otto S Hoekstra1 and Adriaan A Lammertsma1

1 VU University Medical Center, Amsterdam, Netherlands

424

Objectives: To evaluate the test-retest variability of various (semi-) quantitative outcome measures of [18F]FLT studies.

Methods: 9 patients (pts) with non-small-cell lung cancer (NSCLC) and 6 with head and neck cancer (HNC) were scanned twice (within 7 days) using an ECAT EXACT HR+ scanner. Acquisition consisted of a 10 min transmission scan, followed by a 60 min 2D dynamic emission scan, starting simultaneously with administration of 370 MBq [18F]FLT. Volumes of interest (41% threshold) and SUVmax were defined on OSEM reconstructed images summed over 45-60 min p.i. and transferred to FBP reconstructed dynamic images for generating time-activity curves. An input function was obtained by continuous arterial blood sampling for HNC pts and image derived (aorta and/or LV) for NSCLC pts. Corrections for plasma/whole blood ratio and metabolites were based on 6 manual samples. Reproducibility of full kinetic (NLR, Patlak) and simplified (SUV) measures was explored using intraclass correlation coefficients (ICC) and Bland-Altman plots.

Results: A total of 24 lesions in 15 pts was analysed. Except for NLR k3, all measures showed excellent reproducibility.


Figure 1

Bland-Altman analysis did not show dependency on level of FLT uptake and PET estimated tumor volume.

Conclusions: These data suggest that with serial imaging of pts, a change of >14% in SUV41% or >22% in SUVmax and Patlak Ki (>2 SD) is likely to represent a biological effect. NLR k3, selectively reflecting TK1 activity, showed poor reproducibility.





This Article
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Google Scholar
Right arrow Articles by de Langen, A. J
Right arrow Articles by Lammertsma, A. A
PubMed
Right arrow Articles by de Langen, A. J
Right arrow Articles by Lammertsma, A. A