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J Nucl Med. 2008; 49 (Supplement 1):102P
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Oncology-Basic Science: Therapy, Metrics & Intervention

Clinical Radionuclide Therapy

Outcome in well-differentiated papillary thyroid carcinoma after radioiodine ablation therapy

Kim Biermann1, Holger Brockmann1, Samer Ezziddin1, Jan Bucerius1, Kristina Näke1, Hojjat Ahmadzadehfar1 and Hans-Jürgen Biersack1

1 U Hospital Bonn, Bonn, Germany

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Objectives: The aim of this retrospective study was to investigate the impact of several prognostic factors on recurrent/persistent disease and tumor-related survival in well-differentiated papillary thyroid carcinoma (PTC) after radioiodine ablation therapy.

Methods: The institutional database was retrospectively searched for patients with PTC, whose initial therapy consisted of thyroidectomy and radioiodine therapy. Poorly differentiated thyroid carcinoma in histology and unknown survival status at the end of follow-up were exclusion criteria.

Results: n = 749 patients with PTC were included. The median follow-up was 7.8 years. A high T- and initial N1-classification were both significantly associated with occurrence of distant metastases (p<0.0001) and of persistent/recurrent disease in M0-patients (p=0.013 and p=0.001, respectively). Age and gender had no significant impact on development of recurrent/persistent disease or distant metastases. Age ≥ 45 years, a high T-classification, N1- and M1-classification were significantly associated with PTC-related death (p<0.0001, p=0.002, p<0.0001 and p<0.0001). The 10-year survival rate in patients with distant metastases was 63 % and did not differ between patients with or without lymph node metastases (p=0.29). All patients who died from distant metastases (n = 14) were 45 years or older (p<0.0001).

Conclusions: A high T- and initial N1-classification are significantly associated with occurrence of distant metastases and persistent/recurrent disease. Besides presence of distant metastases, age ≥ 45 years, a high T- and an initial N1-classification are significantly related to impaired survival.





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