J Nucl Med. 2007; 48 (Supplement 2):277P
General Clinical Specialties: Gastroenterology
Gastroenterology Posters |
FDG-PET/CT imaging using an intravenous drip injection of scopolamine butylbromide as an inhibitor of physiologic uptake in the stomach
Katsumi Tamura1,
Ikuko Sakata1,
Jirou Ishida1,
Kyosan Yoshikawa2,
Hiroyuki Ishikawa2,
Atsushi Kubo3,
Shigeru Kosuda4,
Kikuo Machida1 and
Yoshiyuki Abe1
1 Tokorozawa PET Diagnostic Imaging Clinic, Tokorozawa-shi, Saitama-ken, Japan; ;
2 National Institute of Radiological Sciences, Chiba-shi, Chiba-ken, Japan; ;
3 Radiology, Keio University Hospital, Shinjyuku-ku, Tokyo, Japan; ;
4 Radiology, National Defence Medical College, Tokorozawa-shi, Saitama-ken, Japan
1249
Objectives: 18F-FDG frequently accumulates in the normal stomach. So, the gastric uptakes often pester nuclear medicine physicians with the interpretation as to whether " uptakes in the stomach are normal or not." The purpose of this study is to assess the ability of scopolamine butylbromide that inhibits the periatalsis of the gastrointestinal tract to reduce the physiologic uptakes in the stomach. Methods: Eighty-three people who had a checkup for cancer using PET/CT in 2005-2006 were studied. Mean age was 43.9 years old. Thirty-four people were female and forty-nine people were male. We administered an intravenous drip injection of isotonic sodium chloride solution including scopolamine butylbromide of 20mg to the half of people in this study for 30 minutes. The drip was started at five minutes before the injection of 18F-FDG. We categorized the degree of gastric uptake into four grades according to the following scale: Grade 0: no visible uptake; Grade 1: uptake in the stomach lower than in the liver; Grade 2: uptake in the stomach is similar to the liver; Grade 3: uptake in the stomach higher than in the liver. Also, we placed the ROI including the highest uptake area in the stomach (circle ROI, 10mm in diameter) and measured SUV. Results: The Grade of drip injection group was averaged 1.15±0.69SD, and the Grade of non drip injection group was averaged 2.24±0.85SD. The average Grade of drip injection group was significantly lower than that of non drip injection group (p<0.0001). The half of people in the non drip injection group (21/42) showed Grade3, but only 7.32% of people in the drip injection group (3/41) showed Grade3. The SUV in the stomach averaged 3.04±1.07SD in the drip injection group, and 3.72±1.08 in the non drip injection group. The averaged SUV in the drip injection group was significantly lower than that in the non drip injection group (p=0.0051). Conclusions: Our results indicate that the intravenous drip injection of scopolamine butylbromide is an effective method to reduce the physiologic uptake in the stomach.
